Current Clinical Trials

The Medical Research Center of Connecticut was founded by Gastroenterology Center of Connecticut physicians in 2000. Our mission is to provide high quality care to our patients offering the opportunity to participate in clinical trials involving established and promising new treatments for gastrointestinal and liver disease.

We are currently enrolling participants in the following studies:

Ulcerative Colitis
  • AbbVie Protocol M14-234

    A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis
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  • AbbVie Protocol M14-033 (High Dose Induction)

    A Double-Blind, Randomized, Multicenter Study of Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis
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Crohn's
  • Protocol I6T-MC-AMAG  (SERENITY)

    A Phase 2, Multicenter, Randomized, Parallel-Arm, Placebo-Controlled Study of LY3074828 in Subjects with Active Crohn’s Disease
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  • AbbVie Protocol M14-115 (Adalimumab high dose induction)

    A Multicenter, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Two Adalimumab Induction Regimens in Subjects With Moderately to Severely Active Crohn's Disease and Evidence of Mucosal Ulceration
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  • Takeda (Vedolizumab) Protocol MLN 3031

    A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Vedolizumab Subcutaneous as Maintenance Therapy in Subjects With Moderately to Severely Active Crohn’s Disease Who Achieved Clinical Response Following Open-Label Vedolizumab Intravenous Therapy
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IBS - Constipation
  • None at this time

IBS - Diarrhea
  • None at this time

Other Studies
  •  SeraTrials - Protocol 05035

    Prospective Collection of Samples for Research: Objective is to obtain blood and/or biological samples from donors who have or have been screened for a variety of identifying characteristics and associated illness, as well as normal controls

  • Eosinophilic Esophagitis (EoE)

    FLUTicasone in Eosinophilic esophagitis (FLUTE): A Randomized, Double-blind, Placebo-controlled, Dose-ranging, and Maintenance Study of APT-1011 in Subjects with Eosinophilic Esophagitis
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Registries
  • Legacy Registry P11-282

    A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of HUMIRA®(Adalimumab) in Patients with Moderately to Severely Active Ulcerative Colitis (UC)

  • Entyvio PASS Registry

    Entyvio (vedolizumab) long-term safety study: An international observational prospective cohort study comparing vedolizumab to other biologic agents in patients with ulcerative colitis or Crohn’s Disease.
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C.Diff
  • Seres 012 - ECOSPOR III

    A Phase 3 Multicenter, RandomizeEd, Double-Blind, Placebo-COntrolled, Parallel-Group Study to Evaluate the Safety, Tolerability, and Efficacy of SER-109 vs. Placebo to Reduce Recurrence of ClOstRidium Difficile Infection (CDI) in Adults Who Have Received Antibacterial Drug Treatment for Recurrent CDI (RCDI).
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  • C.diff Vaccine:  CLOVER

    A PHASE 3, PLACEBO-CONTROLLED, RANDOMIZED, OBSERVER-BLINDED STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF A CLOSTRIDIUM DIFFICILE VACCINE IN ADULTS 50 YEARS OF AGE AND OLDER.
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  • Rebiotix PUNCH CD3

    A Phase 3 Prospective, Randomized, Double-blinded, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of Rebiotix RBX2660 (microbiota suspension) for the Prevention of Recurrent Clostridium difficile Infection.

  • American Gastroenterological Association (AGA) FMT Registry

    A national data registry of patients receiving fecal microbiota transplantation (FMT) or other gut-related-microbiota products designed to prospectively assess short and long-term safety and effectiveness.
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If you are interested in learning more about the Medical Research Center of Connecticut or the studies in which we participate, please contact Jennifer Nikolich, our Research Nurse Administrator, at (203) 281-5161.