Dr. Jaffe was born and raised in suburban New York and has returned "home" after training and practicing in different areas of the country. He graduated from the State University of New York at Binghamton earning a Bachelor of Science Degree and received the Biochemistry award for scholarly excellence upon graduation. He then attended the Albert Einstein College of Medicine in New York City, earning his medical degree in 1985. He then moved to Tucson, Arizona, where he completed his residency training in Internal Medicine at the University of Arizona Health Sciences Center. He was selected to be a chief resident and served with distinction, winning the Excellence in Teaching award during that year.

During his residency training, Dr. Jaffe found special interest in the study of digestive diseases and was honored to be selected to the University of Arizona Health Sciences Center gastroenterology fellowship training program, which he completed in 1991. He received the Outstanding Houseofficer Teaching award at the University of Arizona and was appointed to the faculty where he served until 1999. During that time, he received a number of awards and was named as one of "America's Best Doctors" for four consecutive years and was invited to speak at innumerable national and international meetings.

At the University of Arizona he became the medical director of gastrointestinal endoscopy and head of clinical gastroenterology. In 1999, he was selected to head up the GI Section of the newest branch of the Cleveland Clinic Foundation in Naples, Florida. After moving there, he was named the medical director of gastrointestinal endoscopy and then became the chairman of the Department of Medicine.

In 2002 Dr. Jaffe returned to the northeast where he became the medical director of gastrointestinal endoscopy and then the chief of clinical gastroenterology at the University of Connecticut Health Center in Farmington until joining the Gastroenterology Center of Connecticut. His specialty interests include esophageal reflux disease, Barrett's esophagus, swallowing disorders, esophageal and stomach tumors, disorders of the gallbladder and biliary tract, pancreatic diseases, colon and rectal cancer prevention and treatment. He has highly specialized training in endoscopic ultrasound evaluation of the gastrointestinal tract, endoscopic techniques to evaluate and treat biliary tract obstruction (ERCP), and new techniques to non-surgically destroy tumors from the inside of the esophagus, stomach, and colon (endoscopic mucosal resection, laser therapy, argon plasma coagulation).